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The bulk of the urine-recovered dye must have been taken up into the sexy layer of the skin and then slowly launched into the circulation. A cumulative 4-day absorption assuming cm 2 of scalp was given as 0.
According to the results obtained, Daphnia magna is essentially the most sensitive organism, and resorcinol could be categorised as acutely toxic only to Daphnia. However, this worth is questionable to be used as a restrict value in danger evaluation that is the very best concentration examined on this research , and the NOEC could possibly be considerably greater than stated within the research. In the environment, resorcinol is quickly degraded half-life about 2 h by response with photochemically produced hydroxyl radicals. Under aerobic conditions, resorcinol proved to be readily biodegradable in a take a look at conducted according to OECD TG C, and it is more likely to be biodegraded beneath anaerobic situations.

No resorcinol-related macroscopic findings, organ weight, or adverse microscopic goal organ effects had been observed in the F zero and F 1 parental animals. The F 0 and F 1 females continued to obtain the resorcinol all through mating, gestation, and lactation and through the day of euthanasia for examine design, see Appendix 7. There were no F 0 and F 1 parental resorcinol-related deaths or clinical findings through the weekly detailed bodily examinations. In controls and the excessive-dose group, a qualitative histopathological analysis of the mind forebrain, midbrain, and hindbrain was also performed for the aforementioned animals RTF, There have been no opposed effects regarding reproductive performance, mortality, and body or organ weights.

Animals that died confirmed hyperaemia and distension of abdomen and intestine, whereas there were no gross lesions at necropsy in survivors Flickinger, In another research with CFY rats. Most of the research are of sufficient quality and acceptable for danger characterization functions.
British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The effect of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there are no epidemiological knowledge relevant to the carcinogenicity of resorcinol in people and that the proof of its carcinogenicity in animals is inadequate; thus, resorcinol is not classifiable as to its carcinogenicity to humans. JECFA assessed the hazards from the use of resorcinol as a meals flavouring agent and concluded that this use is of no security concern. Overall, the research usually are not enough for a statistical extrapolation technique according to the EU Technical Guidance Document EC, a.

• The third study, carried out in , included of active employees.





• Assuming a body weight of 64 kg IPCS, provides an exposure estimate of 0.





• Most of the research are of enough quality and acceptable for threat characterization functions.





• Further particulars were not given.





• Two lengthy-term research with Swiss mice or NZW rabbits, where the animals were handled with 0.





• British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat.

In in vitro human skin research, resorcinol was evaluated from a consultant hair dye formulation that contained 0. However, it ought to be considered that acned skin could also be damaged due either to scratching or to the blemishes themselves.
There are differences in thyroid physiology between people and animals. The weight of evidence suggests that rodents are extra delicate to thyroid results than humans.

In each species, there were no opposed effects on last imply body weights, haematology, or medical chemistry parameters, and no chemical-associated gross or microscopic lesions had been noticed. In another research, rats were exposed to 0 or zero. No thyroid hormone measurements have been carried out.
The microscopic examination of the thyroid gave minimal adjustments follicular hyperplasia , which were statistically not important between controls and individual dose teams RTF, In vitro research have been carried out to evaluate the results of resorcinol on thyroid function. In excessive-dose teams, a lower in physique weight and decreased survival were noted. Owing to concern concerning the thyroid results of resorcinol, which have been shown in human studies to occur at high doses, this finish-level specifically has been the point of focus in a number of studies. In many of the older research, the consequences of resorcinol exposure on the thyroid gland are conflicting. It has been instructed that thyroid effects appear to be depending on an administration route that enables for continued systemic exposure e.

There have been no revealed animal research showing thyroidal effects with a dose—response relationship that could be used for a tolerable consumption. In the body of a full life cycle toxicity take a look at OECD TG , Lima observed no adverse effects after 48 h of exposure at the highest concentration examined, zero. Furthermore, Cronin et al. The fish and pond snails had been placed directly into the aquaria, while the remaining five species had been segregated in several baskets and suspended in the aquaria. The only investigation into this finish-level is that from the dose range-discovering study reported in sections eight.
One factor increasing potential poisonous results is the application of resorcinol to injured pores and skin Cassano et al. Surviving F zero parental and F 1 following selection rats underwent complete gross necropsy following the breeding interval seven F 0 males per group , following completion of weaning of F 1 pups F zero females , following scheduled necropsy of F 0 females remaining seven F 0 males per group , on PND 28 F 1 uncovered pups , or on PND 30 or 70 F 1 pups selected for behavioural testing.
The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and handled pores and skin areas confirmed slight erythema and excessive dryness. Mean knowledge for three donors and sixteen replicates point out a plateau in receptor fluid focus between 24 and 48 h, as reflected by cumulative absorption values of 1. A steady-state permeability coefficient. For male albino rats strain not given;.