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Animals that died showed hyperaemia and distension of stomach and intestine, while there were no gross lesions at necropsy in survivors Flickinger, In another examine with CFY rats. Most of the studies are of enough quality and acceptable for risk characterization purposes.
From its use in topical medication and from limited data from occupational studies, resorcinol does not appear to be irritating to the skin in the concentrations reported. Van Leeuwen et al. There isn't any indication as as to if the teratogenic results have been endocrine mediated or not EC, c. In people, dermal publicity to resorcinol has been reported to be associated with thyroid results, CNS disturbances, red blood cell adjustments, and a low incidence of pores and skin sensitization. Five of 3.

The results had been extra pronounced at 72 h. The irritation index was given as four. However, owing to lacking correlating histopathological adjustments in the three levels of the brain examined and in the absence of a dose—response relationship, other indicators of developmental delay, or other adjustments in CNS function, these results weren't considered as conclusive proof of a change in CNS perform. In the following two-technology reproductive toxicity examine RTF, , these finish-points weren't investigated. No resorcinol-related results on F 0 and F 1 pup survival or the general physical condition of the pups through the pre-weaning interval have been noticed.

In basic, the h LC 50 values for resorcinol have been in the range between In flow-via exams and analytical monitoring, DeGraeve et al. As mentioned in section 9. Complete therapeutic was famous after about 1 week of absence from work. However, with growing resorcinol concentrations, there was additionally an increase within the number of persons who examined positive. Resorcinol was additionally tested in hairdressers, who might have been in touch with resorcinol-containing hair dyes.

• Owing to concern concerning the thyroid results of resorcinol, which have been shown in human studies to happen at excessive doses, this end-level in particular has been the purpose of focus in a number of studies.





• Experimental knowledge on soil sorption utilizing silty loam indicate a really low potential for geoaccumulation.





• As is well known in dermal absorption studies, the character of the car has a fantastic affect on the absorption of a compound.





• According to the outcomes obtained, Daphnia magna is probably the most sensitive organism, and resorcinol can be categorised as acutely poisonous only to Daphnia.





• Flaked resorcinol brought on no perceptible to average irritation intact skin or no perceptible necrosis abraded skin.

There isn't any guideline study on toxicity for aquatic plants available. As only one concentration was tested, the research cannot be used within the threat evaluation. There are several research out there on acute toxicity to different fish species.
The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and handled pores and skin areas confirmed slight erythema and extreme dryness. Mean data for 3 donors and 16 replicates indicate a plateau in receptor fluid concentration between 24 and forty eight h, as reflected by cumulative absorption values of 1. A regular-state permeability coefficient. For male albino rats strain not given;.

The third study, performed in , included of energetic staff. In topics males, thirteen girls with a imply age of 37 years, each laboratory and other checks, including medical examination, have been carried out; no irregular thyroid glands or modifications in T four values have been found in any of the subjects when compared with regular values Bauer, The above information are limited due to small research sizes, lack of comparison teams, missing current and historical management data, and lacking information concerning potential exposure classes. In a examine in a plant producing resorcinol by sulfonation of benzene — and likewise producing beta -resorcylic acid, resorcinol—formaldehyde resins, sulfites, and sulfates — workers have been exposed primarily to resorcinol, but the publicity to other agents was not measured for exposure levels, see section 6. In this plant, three cross-sectional studies have been carried out between and Flickinger, In , medical examinations, chest X-rays, pulmonary function, haematology, and medical chemistry were carried out with of individuals actively employed at a production plant in Pennsylvania, USA. In addition, male rats have greater circulating ranges of TSH than females.

The microscopic examination of the thyroid gave minimal adjustments follicular hyperplasia , which have been statistically not vital between controls and particular person dose teams RTF, In vitro studies have been performed to assess the consequences of resorcinol on thyroid function. In high-dose groups, a decrease in physique weight and decreased survival had been noted. Owing to concern concerning the thyroid effects of resorcinol, which have been proven in human research to happen at excessive doses, this finish-point specifically has been the point of focus in several research. In many of the older studies, the consequences of resorcinol exposure on the thyroid gland are conflicting. It has been advised that thyroid effects appear to be dependent on an administration route that enables for continued systemic publicity e.
In each species, there have been no opposed results on ultimate imply body weights, haematology, or scientific chemistry parameters, and no chemical-associated gross or microscopic lesions had been observed. In one other research, rats were uncovered to zero or zero. No thyroid hormone measurements have been carried out.